Under the action of TGF‐β, bone marrow‐derived MSCs (BM‐MSCs), adipocyte‐derived stem cells and smooth muscle cells differentiate into CAFs, promoting the progression of tumours, such as B‐cell acute lymphoblastic leukaemia, glioma, breast, pancreatic, or gastric tumour.18, 19, 20. This evidence concerns the gene TGFB1 and neoplasm.