However, L1CAM is highly expressed in kidney, urinary bladder and skin (https://www.proteinatlas.org/ENSG00000198910‐L1CAM/tissue), and it is overexpressed in many human cancers in organs outside of the CNS (Ganesh et al., 2020; Giordano & Cavallaro, 2020). The gene discussed is L1CAM; the disease is cancer.