Based on GENIE data, KIT mutations significantly co-occurred with CDH1 (p = 0.012) and TERT (p = 0.047) mutations and were mutually excluded with NRAS (p = 0.013) and BRAF (p = 0.039) mutations, whereas mutual exclusivity also was observed between CDH1 and NRAS mutations (p = 0.047) and NRAS and BRAF mutations (p = 0.001) in cutaneous melanomas. This evidence concerns the gene CDH1 and cutaneous melanoma.