The CDH1 gene is a known tumor-suppressor gene, and the loss of E-cadherin expression is an important indicator of metastatic potential and it is associated with tumor metastases in a wide range or tumors (gastric, breast, colorectal, thyroid, and ovarian tumors).23 Studies focused on melanoma have shown that normal expression of E-cadherin inhibits the invasion of melanoma cells into the dermis by downregulating invasion-related adhesion receptors and inducing apoptosis. The gene discussed is CDH1; the disease is melanoma.