In melanoma, KIT mutations have been historically associated with mucosal and acral melanomas20 and only rarely have been identified in the metastases of stage IV cutaneous melanomas of sun-damaged areas.21 In our cohort, a KIT mutation found in stage IIB or IIC cutaneous melanoma was associated with a higher risk for metastasis, specifically distant metastasis. The gene discussed is KIT; the disease is melanoma.