ACTA1 and Myocardial fibrosis: The mRNA expression levels of collagen (COL1A1 and COL3A1) and α-SMA, which are markers of myocardial fibrosis, were significantly elevated in the Ang II group compared to the saline group, but muscone treatment significantly suppressed the elevated mRNA levels of α-SMA, COL1A1, and COL3A1 (Fig. 2L-N).