In order to explore the role of CPEB2 in the occurrence and development of glioma, we first analyzed the expression levels of CPEB2 in glioma patient cohorts, and identified that CPEB2 was significantly downregulated in glioma. We further studied its role in glioma cell proliferation by CPEB2 overexpression or knockdown, and we demonstrated that CPEB2 could inhibit glioma cells proliferation in vivo and in vitro. The gene discussed is CPEB2; the disease is glioma.