A comprehensive meta-analysis that included three trials (PROGRESS, PRoFESS and PATS) aimed to evaluate the efficacy of ACE inhibitors (ACEI), angiotensin receptor blockers and diuretics in preventing stroke recurrence among Chinese patients with IS. The findings indicated that the type of medication did not influence the risk of stroke recurrence.241 Several clinical trials indicated that compared with ACEI, calcium channel blockers and placebo, beta-blockers may not significantly reduce the risk of stroke.242–244. This evidence concerns the gene ACE and stroke disorder.