It is worth noting that midline gliomas in adults represent DMG in 15–60% of cases, most frequently located in the thalamus.31, 32The remaining minority of DIPGs in children without H3-K27 alteration may represent other types of tumors, including low-grade MYB-altered gliomas, high-grade H3-wildtype and IDH-wildtype gliomas, or even adult-type IDH-mutant gliomas. The gene discussed is IDH2; the disease is central nervous system cancer.