The remaining four types are high-grade and consist of diffuse midline glioma, H3 K27-altered (DMG); diffuse hemispheric glioma, H3 G34-mutant (DHG); diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype; and infant-type hemispheric glioma.5 Here, IDH1 is linked to central nervous system cancer.