IDH1 and central nervous system cancer: These tumors are consistently IDH and H3 wild-type.8PLNTY is marked by genetic alterations in the MAPK pathway and features a V-Raf murine sarcoma viral oncogene homolog B1(BRAF) V600E gene mutation in ∼48% of cases; fibroblast growth factor receptors (FGFR) gene fusions may also be present.9Angiocentric glioma invariably displays MYB alterations.2