CCR2 and Decreased total monocyte count: 69–71 CCR2-deficient mice also have poor recruitment of monocytes, DCs, and neutrophils to sites of mycobacterial infection and to the draining lymph nodes, impairing the priming of T cells to produce IFN-γ.71,72 In contrast, CCR2-deficient patients appear to have a narrower infectious phenotype restricted to pulmonary infections, recurrent otitis, and mycobacterial disease, perhaps due to the absence of the monocytopenia that occurs in CCR2-deficient mice.