RNF170 and abscess: Subsequent bioactivity of staphylococcal adenosine synthase A (AdsA), a cell surface-anchored 5’-3’-nucleotidase that is also expressed in other predominant Gram-positive pathogens including Streptococcus pyogenes [9,11,19], converts Nuc-liberated deoxyribonucleotides into deoxyadenosine (dAdo) and deoxyguanosine (dGuo), both purine death-effector deoxyribonucleosides that exquisitely kill macrophages during abscess formation [11,20].