The proteoglycans in cancer, axon guidance, and lysosome were significantly enriched in CAFs at early developmental stages (cluster 1) (Figure 10A); The pathways in cancer, IL-17 signaling pathway, and cytokine-cytokine receptor interactions were significantly enriched in CAFs at mid-developmental stages (cluster 5) (Figure 10B); The cell cycle, DNA replication and mismatch repair pathways were significantly enriched in CAFs at the late developmental stage (cluster 3) (Figure 10C). The gene discussed is IL17A; the disease is cancer.