GSEA analyses revealed that HCC patients with high CMscore were enriched in cancer-related pathways like mitotic nuclear division, meiotic cell cycle process, WNT signaling pathway, and ERBB signaling pathway (Figure 4C–4F and Supplementary Table 4), and in immune related pathways like positive regulation of leukocyte cell cell adhesion (Figure 4G–4J, Supplementary Table 4), whereas patients with low CMscore were enriched in metabolism-related pathways like organic acid catabolic process and lipid oxidation (Figure 4K–4N and Supplementary Table 5). Here, EGFR is linked to hepatocellular carcinoma.