Following the analysis of immune cell infiltration in the bulk datasets, we found that the oxidative stress-related score negatively correlated with the ImmuneScore, T cells CD8, T cell CD4 memory activated cells and M1 macrophages (Supplementary Figure 5), confirming that a low OSRS was related to anti-humoral immune activation, as CD8+ T cells, CD4+ T cells and M1 macrophages played essential roles in tumor suppression in the TME [62–64]. This evidence concerns the gene CD4 and neoplasm.