In a cross-sectional study (n = 70) of participants in the chronic phase of stroke recovery, fatigue score was significantly positively correlated with the level of both IL-6 and CRP, although this relationship was no longer statistically significant once entered into a linear regression model with cardiovascular covariables.20 Therefore, PSF may not be a direct result of inflammation, but may be driven by a matrix of other factors such as the stroke associated cardiovascular risk factors (e.g. diabetes, hypertension). This evidence concerns the gene IL6 and Stroke.