miRNA‐486‐5p secreted from the exosomes of RA Fibroblast‐like synoviocytes (RA‐FLS‐Exo) has been reported to promote osteoblast differentiation in RA patients by decreasing the expression level of Tob1 gene and triggering the bone morphogenetic protein (BMP)/Smad pathway.36 Here, TOB1 is linked to rheumatoid arthritis.