There exists a genetic and biological association between coronavirus disease 2019 (COVID‐19) and osteoarthritis (OA) λ matrix metalloproteinases 9, ATF3, CCL4, RELA are higher expressed in both COVID‐19 and OA λ Bioinformatics analysis identified potential diagnostic methods and therapeutic strategies toward the co‐morbidity of COVID‐19 and OA. This evidence concerns the gene RELA and COVID-19.