For example, HMGB1/RAGE signaling synergically enhances TGF‐β1‐induced broncho‐airway remodeling and epithelial‐mesenchymal transformation (EMT) by promoting Th17 cell differentiation and IL‐17 secretion, which is one of the causes of severe steroid‐resistant asthma.94 The gene discussed is TGFB1; the disease is asthma.