It is reported that HMGB1 levels in sputum of asthmatic patients are significantly increased and positively correlated with asthma severity, obesity, and neutrophil percentage and significantly increased in lung tissue and bronchoalveolar lavage fluid (BALF) of asthmatic rats induced by ovalbumin (OVA) and positively correlated with obesity.79, 80, 81. Here, HMGB1 is linked to obesity due to melanocortin 4 receptor deficiency.