However, K18-hACE2 C57CL/6J mice do not constitute an adequate model for the investigation of this phenotype in the context of a co-infection with SARS-CoV-2, as the overexpression of hACE2 in the brains of these mice has been linked to lethal viral neurodissemination and encephalopathy (Fumagalli et al., 2022), which is not typically observed during human SARS-CoV-2 infection. This evidence concerns the gene KRT18 and coinfection.