AKT1 and colorectal carcinoma: According to relevant studies, it can be reported that apoptosis of CRC cells can be induced by inhibiting the activity of glutamate dehydrogenase, regulating the MAPK signaling pathway, PI3K/AKT, and other related pathway mechanisms, which are crucial for the development of CRC (Chang and Kang, 2023; Yang et al., 2023).