NFKB1 and colorectal carcinoma: These compounds produce regulatory cytokines, like TNF-α, which leads to the activation or blocking of NF-κB, and they also activate pro-apoptotic proteins (Bcl-1, Bad, Bax, Bak), combine cytochrome C with caspase-9 to form an apoptotic complex, and ultimately promote CRC cells apoptosis.