Furthermore, the expression of DRP1 increases in cardiac hypertrophy,109, 110 the levels of MFN1 and MFN2 decrease in patients with idiopathic dilated cardiomyopathy111, 112, 113 and HF,70 respectively, and these effects are correlated with increased mitochondrial fragmentation in the heart. Here, MFN2 is linked to hydrops fetalis.