OPA1 and acute myeloid leukemia: OPA1 and MFN1 are upregulated in ovarian, breast, liver cancer, AML, esophageal, renal, and stomach cancer (Table 3), and another RNAseq data have also stressed the significant mRNA overexpression of OPA1 in a variety of tumor types, including breast, renal, stomach, and esophageal cancer.