Future studies could explore the function of MIB2 in the HOIP-epidermal knock-out (EKO) (50, 51), OTULIN-EKO (52, 53), and NEMO+/− (54, 55) mice, in the topical imiquimod model, or in the more recently described model of psoriasis caused by an autoactivating mutation in ras-related C3 botulinum toxin substrate 1 (RAC1), RAC1V12 (56). The gene discussed is RNF31; the disease is psoriasis.