ACE and type 2 diabetes mellitus: The protein levels of ACE2 and MasR were significantly reduced in the liver of T2DM mice (57.3% reduction and 63.4% reduction, respectively, as compared with the CNTR group, Figures 6A–C), while the protein levels of AT1 and ACE were increased (155.1% increase and 191.7% increase, respectively, as compared with the CNTR group, Figures 6A,D,E).