Previous studies have utilized a surrogate measurement of E-cadherin and N-cadherin by evaluating tumor expression of miRNAs, long noncoding RNAs (lnRNAs), exosomes, or other RNA fragments, however, direct serum measurement of E-cadherin may offer greater insight on malignancy potential than upstream effector molecules [9, 45]. Here, CDH1 is linked to neoplasm.