Research has shown that EMT is associated with increased expression of mesenchymal markers, such as vimentin and N-cadherin, and decreased expression of epithelial markers, such as E-cadherin, in osteosarcoma cells [2], [12]. A complex web of signaling pathways known to downregulate E-cadherin expression and upregulate mesenchymal markers is involved in mediating EMT [13]. Here, CDH2 is linked to osteosarcoma.