Supplementary Figure S1A provides insight into the model’s performance during each round of leave-one-out cross-validation. This plot indicates the reliability and robustness of the analysis results for the association between MPO and OSA. The funnel plot in Supplementary Figure S1B suggests that there is no evidence of bias or heterogeneity, indicating the reliability of the results and the relationship between MPO and OSA. This evidence concerns the gene MPO and obstructive sleep apnea syndrome.