The present study showed that MMP-2 levels in the gingiva were upregulated in both WT and Spock1-Tg mice (Supplementary Figure S2A), and active-MMP-2 levels in the gingiva were upregulated in Spock1-Tg mice and experimental periodontitis (Figures 4D,E). The gene discussed is SPOCK1; the disease is periodontitis.