Therefore, in this study, we combined the DIGO model induced by ligature-induced periodontitis and CsA administration with the EMT model overexpressing SPOCK-1, which was established in our previous study, to evaluate the degree of gingival thickening, alveolar bone resorption, and related gene expression in mice and understand the roles and interactions of periodontal infection/inflammation, the CN/NF-AT axis, and EMT in the pathogenesis of DIGO. This evidence concerns the gene SPOCK1 and periodontitis.