As previously reported (Okanobu et al., 2017), CsA-treated WT and Spock1-Tg mice showed distinct gingival overgrowth on the occlusal and buccal sides in response to ligature-induced periodontitis compared to ligature-treated WT and Spock1-Tg mice without CsA treatment (Figures 3B–E). The gene discussed is SPOCK1; the disease is periodontitis.