The inhibition of TRPV4 diminishes the expression of tumor necrosis factor‐α (TNF‐α) during hypo‐osmolarity,21 and the ablation of TRVP4 in annulus fibrosus (AF) cells reduces interleukin‐6 (IL‐6) and IL‐8 production during hyperphysiological stretching.20, 21, 22. Here, TRPV4 is linked to atrial fibrillation.