Anti-obesity, cardioprotective, anticancer, antitumor, antidiabetic, antioxidant, anti-age effects, and glucose metabolism, inhibited CYP2E1, which prevented acetaminophen (APAP)-induced liver damage in mice by controlling oxidative stress by regulating the expression of glutathione-related metabolites and enzymes. This evidence concerns the gene CYP2E1 and obesity due to melanocortin 4 receptor deficiency.