In accordance with these observations, analyses of RNA-seq data obtained after 24 and 48 h of infection revealed that cardiomyocyte infection caused an increase in gene expression of Epac1 and Rap1b, while Rap1GAP2, a protein that induces inactivation of Rap1b, presented a decreased expression (Venturini et al., 2023). Here, RAPGEF3 is linked to infection.