Taking into consideration that cAMP-dependent invasion of the host cell is mediated by activation in the host of the Epac1/Rap1b pathway (Musikant et al., 2017; Ferri et al., 2023), and that this pathway has already been targeted in numerous human disorders before, we hypothesized that aiming Epac/Rap1b would be an interesting strategy to suppress T. cruzi invasion as a potential new therapy against the parasite infection. This evidence concerns the gene RAPGEF3 and parasitic infectious disease.