In addition to the domains conservatively associated with viral replication, a 2OG-Fe(II) oxygenase superfamily (CDD accession cl21496) (Aravind and Koonin, 2001) and an ovarian tumor (OTU) superfamily (CDD accession cl45892) (Messick et al., 2008) were found in the intergenic region between MTR and HEL (Figure 1), with lower E-value of about 1e-10 to 1e-12. Here, MTR is linked to ovarian neoplasm.