The clinical relevance and prognostic value of 9p24.1 gene alteration in an independent cohort of HCC patients were studied by tissue microarray analysis, and the results showed that the genetic alteration of 9p24.1 significantly promoted the upregulation of PD-L1 and PD-L2 (56). This evidence concerns the gene PDCD1LG2 and hepatocellular carcinoma.