For further comparison of CISD2 expression among B-cell lines, first, CISD2 expression of DLBCL cell lines, including DB, SUDHL4, and SUDHL2, was upregulated compared with normal B cell lines (GM12878) through WB analysis (Supplementary Figures S1C, D) and qRT-PCR analysis (Supplementary Figure S1E). Here, CISD2 is linked to diffuse large B-cell lymphoma.