Based on TIMER2.0 (http://timer.cistrome.org), we found that CISD2 expression was upregulated in numerous tumors (7) (Supplementary Figure S1A), including lung adenocarcinoma (LUAD) (33), breast cancer (BRCA) (10, 34), and liver cancer (LIHC) (35). Here, CISD2 is linked to invasive breast carcinoma.