Several studies showed that apoptosis proteins such as P53 (63, 64), BCL2 (65–67), and MCL1 (68), directly and indirectly involved in the intrinsic or extrinsic apoptotic pathways in the regulation of pathophysiology and chemotherapy resistance in DLBCL (5, 51, 67, 69). This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.