Based on TIMER2.0 (http://timer.cistrome.org), we found that CISD2 expression was upregulated in numerous tumors (7) (Supplementary Figure S1A), including lung adenocarcinoma (LUAD) (33), breast cancer (BRCA) (10, 34), and liver cancer (LIHC) (35). This evidence concerns the gene CISD2 and liver cancer.