On the other hand, activating mutations in CTNNB1 and other genetic alterations in canonical Wnt pathway components in ACC induce nuclear translocation of beta-catenin and transcriptional regulation of genes involved in cell proliferation, apoptosis and invasion, being also associated to immune cell exclusion from the tumour (16, 26–31). Here, CTNNB1 is linked to adrenal cortex carcinoma.