While the pathophysiology of long COVID linked cardiovascular disease is far from certain, it may involve viral invasion of cardiomyocytes and cell death, downregulation of Angiotensin-converting enzyme 2 (ACE2), endothelial cell infection, complement activation, deregulation of renin-angiotensin-aldosterone system, autonomic abnormalities, myocarditis and cardiac tissue fibrosis (74–79). The gene discussed is REN; the disease is cardiovascular disorder.