This is supported by several studies reporting an important role of Trem2 and Lrp1 in phagocytosis and neuroprotection in neurological disease (Takahashi et al., 2005; Fernandez-Castaneda et al., 2013; Kawabori et al., 2015; Chuang et al., 2016). The gene discussed is LRP1; the disease is nervous system disorder.