In this context, we describe and postulate that potential specific microRNAs may be involved in the CD133+ endothelial stem-progenitor cell-mediated T-lymphocyte dysfunction in SARS-CoV-2 infection (COVID-19), showing a certain similarity to the incidence of miRNA dysregulation mechanisms of pathogenesis that occur in HIV-1 infection (Padmanabhan et al., 2020). This evidence concerns the gene PROM1 and COVID-19.