Thus, SARS-CoV-2 may confer via ACE2+CD133+ ESPC (Koka et al., 2020), a contrasting reciprocal involvement of miRNA in the onset of cytokine storm in T-lymphocytes, and the mechanistic characterization of such may in the future pave the way for novel treatments for COVID-19. Here, PROM1 is linked to COVID-19.