However, these immune cells become pathogenic to this virus, eliciting a profuse cytokine storm through the cytokine dysregulation in these cells; interestingly, this is in an indirect manner following infection of the CD133+CD34+/− ESPC through this virus’ primary receptor ACE2 on the cell surface (Fajgenbaum and June 2020; Gheblaw et al., 2020; Koka et al., 2020; Liu et al., 2021; Kotani et al., 2022). Here, ACE2 is linked to infection.