Importantly, the most upregulated and significant signaling pathway between microglia and DAM communication in 5XFAD brain was PSAP-GPR37L1, related to lysosomal regulation, which accumulates in dystrophic neurites and/or Aβ plaques of AD mice (Sharoar et al., 2021) and patients (Mendsaikhan et al., 2019). The gene discussed is GPR37L1; the disease is Alzheimer disease.