S100A1 and Alzheimer disease: These 109 DEGs corrected by hNSC transplantation contained several genes known to be related to AD pathogenesis (Supplementary Figure S7B), such as Trem2 (Supplementary Figure S8), Tyrobp, S100a1, Igfbp5, and complement C1q. Importantly, expression of these DEGs varied across cell types, and differences were more pronounced in stage 2 DAMs and interneurons (Supplementary Figure S9).