MAPT and Alzheimer disease: Indeed, AD is increasingly thought to proceed through a multifactorial pathology, involving neuroinflammation (Heneka et al., 2015; Arranz and De Strooper, 2019), disrupted metabolism (Serrano-Pozo et al., 2021), and vascular dysfunction, in addition to Aβ and tau pathology (Scheltens et al., 2021).