A number of DEGs in hippocampus are identifiable as AD-related genes, such as the transcription factor Neurod6 regulating nervous system development and differentiation (Li et al., 2015), the peptidase Ctsd controlling protein turnover (Schuur et al., 2011), and glutaminase Gls (Griffin et al., 2018). This evidence concerns the gene CTSD and Alzheimer disease.