This association may be attributed to the ability of short-chain fatty acids (SCFA) to inhibit histone deacetylases (HDAC) and activate the re-expression of transport proteins in thyroid cancer cells, thereby inducing the differentiation of tumor cells and enhancing iodine uptake (Zhou et al., 2018; Rathod et al., 2020). The gene discussed is HDAC9; the disease is thyroid gland carcinoma.