The second gene is the downstream, coding heterogeneous nuclear ribonucleoprotein H2 gene, HNRNPH2. The GLA locus, which is implicated in FD, is mapped in between the RPL36A and HNRNPH2 loci on the reverse strand of the RPL36A-HNRNPH2 readthrough locus (Figure 1A). This evidence concerns the gene GLA and Fabry disease.