Loss of tumor suppressor factors such as p53 and BRCA1 associated protein 1 (BAP1), mutations in proto-oncogenes like KRAS, or overexpression of pro-tumor functional proteins such as OTU domain, ubiquitin aldehyde binding 1 (OTUB1) can lead to an increase in the level of SLC7A11, which is the cystine transporter also known as xCT (19). This evidence concerns the gene BAP1 and neoplasm.