Notably, the intraperitoneal administration of exendin‐4, a glucagon‐like peptide‐1 receptor agonist, downregulated A1 astrocyte activation and alleviated delirium‐like behavior in aged mice, while IL‐1α, TNF‐α, and C1q in combination administered intracerebroventricularly upregulated A1 astrocyte activation and induced delirium‐like behavior in young mice. The gene discussed is IL1A; the disease is delirium.