The MTF2 and PPP6R2 loci contain the genes TMED5 and PPP6R2. Protein TMED5 localizes to Golgi body21 and PPP6C, regulated by PPP6R2, is part of the vesicular transport pathways (https://reactome.org/content/detail/R-HSA-199977)22, both of which are implicated in PD pathogenesis23–28. Here, PPP6C is linked to Parkinson disease.