Intriguingly, in this study, HAT1 was the up-regulated shared NET-related gene and HDAC6, IL-8, SRC, PPIF, PLCG2, PIK3CD, MAP2K1, AKT1, and VDAC1 were the down-regulated shared NET-related genes in IBD and OP. The gene discussed is PLCG2; the disease is inflammatory bowel disease.