GAN DIO-NASH-HCC mice showed significant expansions in myeloid immune cell populations (CD45+CD11b+), dominated by increased number of cells with high expression of Ly6C (Ly6C++), a signature of infiltrating inflammatory monocytes/macrophages27, resident Kupffer-like macrophages (F4/80lowCD11chigh) and dendritic-like cells (F4/80highCD11clow)27, with reciprocal reductions in Ly6G+ neutrophils. This evidence concerns the gene ITGAM and metabolic dysfunction-associated steatohepatitis.