For example, the new evidence towards pathogenicity is much greater for a rare TP53 variant detected in a context with high phenotypical specificity (for example, testing of only one gene, TP53, in an adolescent with rhabdomyosarcoma and a family history of young-onset cancers) compared with a context with low phenotypical specificity (for example, testing of a 40-gene panel in a 68-year-old woman with breast cancer and no family history).19 20, 21 Without data on the tested gene panel and phenotype, the two instances of the variant would not be distinguishable. Here, TP53 is linked to cancer.