SCA3is a deadly neurodegenerative disease against which neithercures, as the neuronal damage produced is irreversible, nor therapeuticstrategies that delay its progression are available.11,38 Since the amyloid aggregation of the ATX3 protein plays a pivotalrole in the disease insurgence, targeting this process through theadministration of substances able to prevent or block this event representsa promising therapeutic strategy.39−41. This evidence concerns the gene ATXN3 and neurodegenerative disease.