Some pathways showed dual roles such as Kras signaling, interferon gram and alpha response, IL6/JAK/STAT3, IL2/STAT5 signaling were negatively enriched in HOXC10 for CESC, COAD, ESCA, HNSC but were positively enriched in HOXC10 for other cancers. This evidence concerns the gene STAT3 and cancer.