We found TNFA signaling via NFKB, reactive oxygen species pathway, PI3K/AKT/MTOR signaling, P53 pathway, oxidative phosphorylation, MTORC1 signaling, glycolysis, fatty acid metabolism, hypoxia and apoptosis were totally positively enriched in HOXC10 for whole cancers. The gene discussed is TP53; the disease is cancer.