TSPYL5 and hepatocellular carcinoma: Another multi-target HCC diagnostic panel based on PCR composed of four DNA methylation markers (HOXA1, EMX1, TSPYL5, and B3GALT6) and two protein markers (AFP and AFP-L3) had a slightly lower sensitivity (80% vs. 84.39%; early stage vs. stage I:71% vs. 75.76%) and specificity (90% vs. 91.92%) than our panel [36].