Other authors describe that probiotics and its metabolites can interfere and protect against viral infections in different ways: (i) inhibition of several reverse transcriptases (Aghebati-Maleki et al. 2022), (ii) stimulating and enhancing the immunological response (Wu et al. 2020; Xie et al. 2022), (iii) enhancing gut immunity (Qiu et al. 2020; Chattaraj et al. 2022), (iv) blocking the viral binding to the host receptors (Kalinichenko et al. 2020), or (v) inducing the expression of mx gene in cells, which could inhibit the NNV RNA synthesis. This evidence concerns the gene MX1 and viral infectious disease.