These findings demonstrate that Tfrc expression correlates with Epor expression, especially in ProE stage, DFP in MDS erythroblasts leads to improvement in EPO-responsiveness not observed in WT mice, and erythroblast cell surface TFR1 for iron uptake during erythropoiesis is coordinated with EPO-responsiveness. This evidence concerns the gene EPOR and myelodysplastic syndrome.