DIO3 and systemic lupus erythematosus: Of these dysregulated miRNAs in lupus, a group of miRNAs is located at the genomic imprinted delta-like homolog 1–type 3 iodothyronine deiodinase (Dlk1-Dio3) locus, which possesses the largest miRNA cluster in human and murine genome (3, 19).