DIO3 and systemic lupus erythematosus: The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of the predicted target genes of the Dlk1-Dio3 miRNAs that are upregulated in murine lupus or in MS showed the enrichment of signaling cascades that have been implicated in autoimmune disease pathogenesis (Supplemental Fig. 1) (20, 21).