To test the potential epigenetic regulatory role of EGR2 in lupus CD4+ T cells, we evaluated the expression of selected methylation-sensitive Dlk1-Dio3 miRNAs, which are highly upregulated in lupus (e.g., miR-127, miR-154, miR-300, miR-279, and miR-433). This evidence concerns the gene EGR2 and systemic lupus erythematosus.