DIO3 and systemic lupus erythematosus: In addition, there is a significant enrichment of Ras-MAPK signaling, FcγR-mediated phagocytosis pathway, TCR signaling, cAMP signaling pathway, HIF-1 signaling, and Wnt signaling pathways in the predicted target genes of lupus-related Dlk1-Dio3 miRNAs, which are also critically involved in autoimmunity and lupus pathogenesis (51–55) (Supplemental Fig. 1).