RYR2 and catecholaminergic polymorphic ventricular tachycardia: Similarly, models have described more indirect alterations (not studied through patch-clamp experiments in heterologous systems) such as the biophysical effects of mutations in cardiac RyR2 channels and CSQ2, providing insight into the subcellular mechanisms of diseases like catecholaminergic polymorphic ventricular tachycardia (CPVT) (206).